Background: Tumour Necrosis Factor-Alpha is a cytokine that helps the immune system and an adipokine that has a role in systemic inflammation connected to obesity and periodontitis. Objectives: This study examined the impact of Body Mass Index (BMI) on salivary Tumour Necrosis Factor Alpha (TNF-α) levels in individuals with periodontitis, both obese and non-obese, as well as in a healthy periodontal control group. Materials and methods: The clinical-biochemical investigation comprised 30 obese periodontitis patients, 30 non-obese periodontitis patients, and 30 periodontally healthy controls. We looked at the periodontal clinical parameters (Gingival Index, Simplified Oral Hygiene Index, Probing Pocket Depth, and Clinical Attachment Level) and anthropometric data (BMI). We also looked at salivary TNF-α levels using an enzyme-linked immunosorbent assay (ELISA). ANOVA and partial correlation coefficient tests were employed to ascertain the extent of the association among TNF-α, periodontitis, and obesity. Results: Salivary TNF-α levels correlated with elevated BMI and CAL; however, no correlation was seen between CAL and BMI values. Individuals with obesity had elevated clinical indices (GI, sOHI, PPD, and CAL), BMI, and TNF-α in comparison to the other two groups. Conclusions: Obesity may not be associated with CAL in periodontal disease; nevertheless, it does correlate with TNF-α levels, which are a critical component in periodontal disease.